GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs1373453 | 1 | rs17106890 | chr12:70052448 | CPSF6 | chr12:69633317-69668137:+ | 0.29 | 4.2 | 3.31E-5 | Orofacial clefts |
| BLCA | cis | rs1373453 | 1 | rs17106890 | chr12:70052448 | LRRC10 | chr12:70002347-70004942:- | 0.21 | 4.07 | 5.82E-5 | Orofacial clefts |
| BLCA | cis | rs17108533 | 1 | rs17108533 | chr14:71249802 | MAP3K9 | chr14:71194856-71275888:- | -0.36 | -4.11 | 4.89E-5 | Response to antipsychotic treatment in schizophrenia (reasoning) |
| BLCA | cis | rs7714584 | 1 | rs17111376 | chr5:150226899 | LOC134466 | chr5:150310000-150326146:- | 0.4 | 4.98 | 9.62E-7 | Crohn's disease |
| BLCA | cis | rs7112513 | 1 | rs17120139 | chr11:116774201 | PCSK7 | chr11:117075789-117102811:- | 0.43 | 5.24 | 2.64E-7 | Protein quantitative trait loci |
| BLCA | cis | rs7789940 | 1 | rs17149161 | chr7:75978229 | UPK3B | chr7:76139745-76157197:+ | -0.3 | -6.33 | 6.76E-10 | Multiple sclerosis |
| BLCA | cis | rs2243480 | 1 | rs1715235 | chr7:65488394 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.42 | 1.31E-5 | Diabetic kidney disease |
| BLCA | cis | rs4722750 | 1 | rs17156099 | chr7:28006442 | HIBADH | chr7:27565063-27702602:- | -0.37 | -3.84 | 0.000144 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| BLCA | cis | rs12748152 | 1 | rs17162339 | chr1:27252823 | GPN2 | chr1:27205873-27216869:- | -0.48 | -4.18 | 3.58E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BLCA | cis | rs11723261 | 1 | rs17164747 | chr4:260587 | ZNF718 | chr4:53272-156488:+ | 0.34 | 4.66 | 4.33E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs9815354 | 1 | rs1716642 | chr3:41965865 | ULK4 | chr3:41288091-42003660:- | -0.63 | -9.71 | 4.41E-20 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs1716644 | chr3:41968028 | ULK4 | chr3:41288091-42003660:- | -0.62 | -9.64 | 8.11E-20 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs1716651 | chr3:41975099 | ULK4 | chr3:41288091-42003660:- | -0.63 | -9.71 | 4.41E-20 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs1716657 | chr3:41918456 | ULK4 | chr3:41288091-42003660:- | -0.64 | -9.91 | 9.53E-21 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs1716660 | chr3:41929960 | ULK4 | chr3:41288091-42003660:- | -0.63 | -9.83 | 1.72E-20 | Diastolic blood pressure |